Julia Arndt, M.Sc.
Phone: +49 (0)711 - 2 29 87 33
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A. Kappel (1), M. Ehm (1)
(1) Pre-Development, Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany
ELISA, immunoassay, luminescent oxygen channeling, latex agglutination
Immunoassays play a pivotal role in the clinical laboratory. In the coagulation section of the laboratory, they are used as an aid for diagnosis of deep vein thrombosis or pulmonary embolism, thrombophilia screening, or detection of coagulation factor deficiencies, respectively. Enzyme-linked immunosorbent assay (ELISA) and latex agglutination immunoassay technologies are currently most widely used, while Luminescent Oxygen Channeling Immunoassay (LOCI®) and other chemiluminescence-based immunoassays are emerging technologies for the coagulation laboratory. However, not all immunoassay technologies employed are compatible with the workflow requirements of the coagulation laboratory, and, not all technologies are suitable for detection or quantification of every marker. This review focuses on technical and performance aspects of those immunoassay technologies that are most widely used in the coagulation laboratory, and provides a description of markers that are typically tested by immunoassays.
P. Bender, H. Bostedt
Tierärztliche Praxis Großtiere 2008 36 2: 73-83
Manfred Rieger 1*, Silvia Ferrari 1*, Johanna A. Kremer Hovinga 2 , Christian Konetschny 1 , Andrea Herzog 1 , Letizia Koller 1 , Alfred Weber 3 , Giuseppe Remuzzi 4 , Michael Dockal 1 , Barbara Plaimauer 1 , Friedrich Scheiflinger 1
Thromb Haemost 2006 95 2: 212-220
A systematic review and meta-analysis
L. Sun (1), P. A. Gimotty (2), S. Lakshmanan (3), A. Cuker (1, 4)
Thromb Haemost 2016 115 5: 1044-1055